Species affected: Mainly chickens, serotype 2 also occurs in turkeys and ducks. Age affected: Young birds ( weeks). Causes: Infectious bursal disease virus . Infectious bursal disease – Immunosuppression – Pathotype – Vaccination. Summary. Introduction in the sector over the sanitary status of poultry. Gumboro. In all poultry producing regions of the world, infectious bursal disease virus (IBDV ) continues to be a major constraint for poultry farmers.

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This raises the question of the origin of vvIBDVs, of the possible existence of reservoirs and of the possible emergence of new, distinct lineages in the future. Diversity of genome segment B from infectious bursal disease viruses in the United States.

Infectious bursal disease Ddisease classification Group: Also, diarrhoea, anorexia, depression, ruffled feathers, especially in the region of the head and the neck are present. Most commonly, IBD begins as a serous bursitis. Structure and Molecular Biology.

Infectious Bursal Disease in Poultry

Oral DNA vaccination with the polyprotein gene of infectious bursal disease virus IBDV delivered by the attenuated Salmonella elicits protective immune responses in chickens. Viruses belonging to one of these antigenic subtypes are commonly known as variants, which were reported to break through high levels of maternal antibodies in commercial flocks, causing up to 60 to percent mortality rates in chickens.

Dual-viral vector approach induced strong and long-lasting protective immunity against very virulent infectious bursal disease virus. At this age the B-lymphoblast population is smaller and the systemic effects are insufficient for generating clinical signs.

Our understanding of IBDV epidemiology has been much more comprehensive by today. A conformational immunogen on VP-2 of infectious bursal disease virus that induces virus-neutralizing antibodies that passively protect chickens. The birnavirus crystal structure reveals structural relationships among icosahedral viruses. Pathological changes, especially haemorrhages, may also be seen in the skeletal muscle, intestines, kidney and spleen.

Acta Biochim Biophys Sin Shanghai. Infectious bursal diseaseIBD also known as Gumboro disease, infectious bursitis and infectious avian nephrosis is a highly contagious disease of young chickens caused by infectious bursal disease virus IBDV[1] characterized by immunosuppression and mortality generally at 3 to 6 weeks of age.

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Mortality rates vary with virulence of the strain involved, the challenge dose, previous immunity, presence of concurrent disease, as well as the flock’s ability to mount an effective immune response.

IBDV DNA vaccines may elicit cell-mediated immunity including memory T-cell responses, 8990 contributing to the protective efficacy of the vaccine. Carrier birds do not appear to exist in recovered flocks and wild birds do not appear to be a significant factor in the spread of the disease. The administration regime of adjuvants may modify their efficacy as shown by Negash et al, 97 who demonstrated that adjuvant application at staggered intervals improved vaccine efficacy compared with simultaneous application of vaccine and adjuvant.

Wild birds, such as healthy ducks, guinea fowl, quail and pheasants, have been found to be naturally infected with IBDV. Virus neutralizing Abs against the conformation dependent neutralizing epitopes can be detected after few days of infection or vaccination and provide protection against antigenetically related viruses.

Immunosuppression of very young chickens, less than three weeks of age, is possibly the most important outcome and may not be clinically detectable subclinical.

In contaminated premises, it could persist for months and in water, forage and faeces for weeks. There are two distinct serotypes of the virus, but only serotype 1 viruses cause disease in poultry.

Tissue culture infectivity of different strains of infectious bursal disease virus is determined by distinct amino acids in VP2. Surface IgM on DT40 cells may be a component of the putative receptor complex responsible for the binding of infectious bursal disease virus.

New alternative prophylactic strategies may be investigated further, including the use of recombinant Abs, recombinant single chain variable fragment Abs, or nanobodies specific for vvIBDV.

Peri-focal vaccination may not be effective for the combat of an outbreak, due to gmboro rapidity of wild-IBDV spreading.

The lesions in the bursa of Fabricius are progressive. Viral-vectored vaccines such as the herpesvirus of turkeys-IBD vaccine were licensed for in ovo and posthatch vaccination of broilers and layers in various countries. The two segments of the infectious bursal disease virus genome are circularized by a 90,Da protein.


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Infectious bursal disease

The enhanced virulence of very virulent infectious bursal disease virus is partly determined by its B-segment. Effective inhibition of replication of infectious bursal disease virus by miRNAs delivered by vectors and targeting the VP2 gene.

IBD virus has a lymphocidic effect and the most severe injuries are in the lymph follicles of the bursa of Fabricius. A preliminary diagnosis can usually be made based on flock history, clinical signs and post-mortem necropsy examinations.

Microparticle MP and nanoparticle delivery systems, particularly those made from biodegradable polymers such as poly lactic- co -glycolic acid PLGA and chitosan have been tested for mucosal delivery of poultry vaccines. This response is mediated by pattern recognition receptors PRRswhich detect pathogen-associated molecular patterns PAMPs for induction of effector molecules.

Expression of perforin-granzyme pathway genes in the bursa of infectious bursal disease virus-infected pouotry. Naturally occurring reassortant infectious bursal disease virus in northern China. For permission for commercial use of this work, please see paragraphs 4.

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Infectious bursal disease – Wikipedia

Gumbkro vaccination against infectious bursal disease in chickens. Infectious bursal disease virus IBDV affects immature B lymphocytes of the bursa of Fabricius and may cause significant immunosuppression. Chicken melanoma differentiation-associated gene 5 MDA5 recognizes infectious bursal disease virus infection and triggers MDA5-related innate immunity.

Another approach to improve vaccine efficacy is to optimize the delivery of candidate vaccines by targeting specific immunological compartments, for example, antigen-presenting cells. Biodegradable microparticles with an entrapped branched octameric peptide as a controlled-release HIV-1 vaccine. When administered per os, IBDV can be detected at 8—12 hours post infection in intestinal mononuclear phagocytic cells, which transport the virus to the BF for extensive replication in B-cells.