Species affected: Mainly chickens, serotype 2 also occurs in turkeys and ducks. Age affected: Causes: Infectious bursal disease virus is a birnavirus. It is highly . Infectious bursal disease – Immunosuppression – Pathotype – Vaccination. Summary. Introduction in the sector over the sanitary status of poultry. Gumboro. In all poultry producing regions of the world, infectious bursal disease virus (IBDV ) continues to be a major constraint for poultry farmers.

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DNA vaccination with VP2 gene fragment confers protection against infectious bursal disease virus in chickens. Reversion of molecularly engineered, partially attenuated, very virulent infectious bursal disease virus during infection of commercial chickens.

Events Latest Events Submit Event. Delayed vaccine virus diwease in chickens vaccinated subcutaneously with an immune complex infectious bursal disease vaccine: Internationally, IBD is also reported endemic in certain areas [ 11 – 13 ]. There are several viral, bacterial, parasitic, and managemental diseases of poultry that cause direct financial loss to farmers.

Infectious bursal disease virus in poultry: current status and future prospects

diseasr Smith et al 62 demonstrated higher expression of NK lysin to approximately fold at 4 days post infection dpi compared with virus-free controls suggesting cytotoxic T-cells and NK cells involvement.

IBD lesions undergo various stages of serous haemorrhagic to severe haemorrhagic inflammation. Sequence and phylogenetic analysis of a Chinese very virulent infectious bursal disease virus.

Sequence comparisons of the variable VP2 region of eight vumboro bursal disease virus isolates. Prevalence of infectious bursal disease Gumboro antibodies in village chickens in Gombe state, northeastern Nigeria.

The coinciding fact in the present study is ppoultry the consideration of mainly layer type birds. Infectious bursal disease live vaccines: Growth and replication of infectious bursal disease virus in the DF-1 cell line and chicken embryo fibroblasts. As the viral capsid protein, VP2 carries immunodominant epitopes responsible for the induction of a protective humoral immune response.

Distribution and quantification of lymphocytes in the major lymphoid organs of naturally gumboro infected broilers. Due to partial protection offered by vaccination, especially by nonreplicating constructs subunit and DNA vaccinesthe development of new adjuvants and adjuvant formulations may help to improve the immunogenicity and protection provided by these vaccines.


Prevention of IBDV-related losses associated with dizease and secondary infections will continue to be a specific focus in the field.

Among them, VP2 protein contains important neutralizing antigenic sites and elicits protective immune response and most of the amino disase AA changes between antigenically different IBDVs are clustered in the hypervariable region of VP2. The genetic basis for the antigenicity of the VP2 protein of the infectious bursal disease virus.

Protective efficacy of intermediate and poultty plus infectious bursal disease virus IBDV vaccines against very virulent IBDV in commercial broilers. In addition to traditional adjuvants, other innovative strategies improving vaccine-induced immunity are under development, including inhibitors of metabolic pathways, modulators of baseline inflammation levels, monoclonal Abs targeting checkpoint inhibitors, poultrry compounds depleting regulatory cells reviewed by De Gregorio Table-2 The scoring of the bursal lesions in six outbreaks.

Outbreak of virulent infectious bursal disease in East Anglia.

Infectious bursal disease – Wikipedia

Naturally occurring reassortant infectious bursal disease virus in northern China. Retrieved from ” https: Immunoadjuvant activities of E. Sequence and phylogenetic analyses of highly virulent infectious bursal disease virus. Peer reviewers approved by Dr Andre Becker Saidenberg. Oral DNA vaccination with the polyprotein gene of infectious bursal disease virus IBDV delivered by the attenuated Salmonella elicits protective immune responses in chickens.

The chicks become anorectic, become reluctant to move, and show ruffled feathers with watery diarrhea, trembling and severe prostration. Diagnosis of infectious bursal disease by immunoperoxidase technique.

In addition, some IBDV live vaccines are expected to maintain poultyr nature, which in the face of selection pressure may favor the outgrowth of more virulent antigenic variants or mutants in the viral population. Response of embryonic chicken lymphoid cells to infectious bursal disease virus.

A non-canonical lon proteinase lacking the ATPase domain employs the ser-Lys catalytic dyad to exercise broad control over the life cycle of a double-stranded RNA virus. As this disease has been focused in recent reviews regarding its causative agent [ 17 ] and the vaccination [ 1819 ], the poultrry study is, therefore, mainly inclined toward the timely and reliable diagnosis of this threatening disease using gross, histopathology HPimmunohistochemistry IHCand immunofluorescent methods.

The affected bursal sections revealed viral antigens in the lesion sites identified in tissue sections, especially inside the cells in the rarefied areas of bursal follicles along with the inner lining of the cystic cavities in affected follicles.


Induction of protective immunity in chickens immunized with plant-made chimeric Bamboo mosaic virus particles expressing very virulent Infectious bursal disease virus antigen. Also, diarrhoea, anorexia, depression, ruffled feathers, especially in the region of the head and the neck are present.

Effective inhibition of replication of ppultry bursal disease virus by miRNAs delivered by vectors and targeting the VP2 gene. VP5, the nonstructural polypeptide of opultry bursal disease virus, accumulates within the host plasma membrane and induces cell lysis. The structure of a birnavirus polymerase disese a distinct active site topology. Tissue culture infectivity of different strains of infectious bursal disease virus is determined by distinct amino acids in VP2.

The enhanced virulence of very virulent infectious bursal disease virus is partly determined by its B-segment. The acute phase of the disease lasts for days and is characterized by atrophy of bursa along with depletion of B-cells [ 7 ] in bursal follicles, the other lymphoid organs such as spleen and cecal tonsils are also affected.

The aim of the present study was to diagnose infectious bursal disease IBD using gross, histopathological, and immunopathological approaches and to compare efficacy of immunohistochemical techniques with conventional diagnostic techniques. The innate immune response is the first-line of defense against pathogens in vertebrate species.

Most isolates of the IBD virus in turkeys are serologically different from those in chickens. Acute infectious bursal disease in poultry: Evaluation of a phylogenetic marker based on genomic segment B of infectious bursal disease virus: Clinical aspects of immunosuppression in poultry.

Omission of primary antibodies was used for negative control. The diagnosis of very virulent infectious bursal disease in California pullets. For a statistical comparison to be drawn, the mean and the standard deviation of the respective histopathological changes were also calculated, as shown in Table Adaptation of a mallard H5N2 low pathogenicity influenza virus in chickens with prior history of infection with infectious bursal disease virus.

Characterisation of chicken viperin.